Oncology

QS scientists have collectively worked on many types of projects involving solid tumors as well as blood cancers. In addition, we have strong scientific knowledge and modeling abilities in translational oncology.

Here are three posters that we participated in at ACOP 2011 in the areas of oncology:

1. Population Pharmacokinetic and Pharmacodynamic Modeling of the Dual PI3K/mTOR Inhibitor GDC-0980 in Phase I Oncology Patients Jin Y. Jin*, Joseph Ware, Hanbin Li, Vikram Malhi, Jenny Wu, Yibing Yan, Jennifer Lauchle, Scott Holden, Mika Derynck, and Mark Dresser

2. Dose Selection Analysis for Pixantrone Dimaleate (BBR 2778) for the Treatment of Patients with Relapsed or Refractory Aggressive Non-Hodgkin’s Lymphoma NL Shasha Jumbe, D Russell Wada, Gabor Jurida, Jack W Singer, Lixia Wang

3. Meta-analysis of Kaplan-Meier overall survival curves from selected randomized controlled Phase II/III trials in advanced melanoma R Wada, Y Feng, N Zhang, A Roy, M Pfister, K Chin, A Hoos, P Mukhopadhyay, TT Chen, E Masson

We have recently developed a paclitaxel mono-therapy database, which includes 1) clinical PK and toxicity information of paclitaxel, and 2) efficacy outcomes on paclitaxel in the treatment of advanced or metastatic breast cancer as well as lung cancer.