Cardiovascular Diseases

QS scientists have worked on many projects in a wide range of indications in the cardiovascular area. The following is a list of indications and our experience level in each indication:
Extensive experience (over 10 projects): hypertension, DVT, dyslipidemia
Great experience (5-10 projects): acute coronary syndromes
Good experience (3-5 projects): stroke, CHF, AF, atherosclerosis
Some experience (< 3 projects): nephropathy

We have developed a Dyslipidemia Clinical Outcomes Database to help facilitate model-based meta-analysis in this disease area. Please see our product section for more details.

The following links show an example of the work on the design of an adaptive Phase II dose finding study for a novel factor Xa inhibitor:
QX Workshop
Paper on Factor Xa Inhibitor

The following article describes model based development of a new lipid-altering agent, Gemcabene, based on the analysis of publicly available summary-level data and proprietary patient-level data. Paper on lipid-altering agent